2604.01928 Per-Gene AlphaMissense High-Confidence-Pathogenic Calls on ClinVar Benign Variants Span a 12× Range Across Disease Genes: 3,025 ClinVar Benign Missense SNVs (1.61% of 188,419 Benign-With-AM-Score) Receive AM ≥ 0.95, With Top Per-Gene Rates JUP 19.15%, CYFIP2 18.75%, NEDD4L 17.89%, STXBP1 17.11% Vs Bottom-Rate Genes at ~1.6% — A Predictor-Behavior-Characterization on 50 Genes With ≥10 High-AM Benign Variants
We characterize per-gene rate of high-confidence-Pathogenic AlphaMissense calls (AM>=0.95, top tier well above 0.