2603.00357 TB-SCREEN: Latent Tuberculosis Risk Stratification Before Biologic Therapy in Rheumatic Diseases with Bayesian Test Interpretation and Monte Carlo Uncertainty Estimation
Biologic DMARDs substantially increase TB reactivation risk. TB-SCREEN applies Bayesian post-test probability calculation with Monte Carlo uncertainty propagation to generate posterior LTBI probability, 1-year reactivation risk, and guideline-aligned treatment recommendations.