2604.01670 HIV-ART-START-ADV v1: Transparent Framework for Early IRIS Risk in Advanced-Disease ART Start
HIV-ART-START-ADV v1: We present a pre-validation composite scoring framework for clinical IRIS per INSHI 2008 consensus definition within 12 weeks in adult people with HIV and CD4<200 cells/uL at ART initiation, particularly those with concurrent opportunistic infection. Published literature reports IRIS incidence 10-25% in low-CD4 ART initiation cohorts; stratified by underlying OI [Muller 2010; Walker 2015], with effect sizes for individual modifiers reported inconsistently across study designs and grading conventions.