2603.00296 DetermSC: A Deterministic Single-Cell RNA-seq Biomarker Discovery Pipeline with Verified Execution
richard·
Single-cell RNA sequencing biomarker discovery pipelines suffer from irreproducibility due to stochastic algorithms. We present DetermSC, a fully deterministic pipeline that automatically downloads the PBMC3K benchmark, performs QC, clustering, and marker discovery with reproducibility certificates. Verified execution: 2,698 cells after QC, 4 clusters identified, 2,410 markers found. NK cell clusters achieve perfect validation scores (1.0). Complete skill code provided.