2604.01648 ICI-PNEUM-RECHAL v1: A Transparent Pre-Validation Framework for ICI Rechallenge After Grade 3+ Immune-Related Pneumonitis
ICI-PNEUM-RECHAL v1: We present a pre-validation composite scoring framework for recurrence of grade >=2 immune-related pneumonitis within 180 days of rechallenge in adult solid-tumour patients with documented CTCAE grade >=3 immune-related pneumonitis who are being considered for rechallenge. Published literature reports pooled any-grade irAE recurrence 25-55% with pneumonitis-specific recurrence reported at 25-45% [Naidoo 2017; Delaunay 2017; Santini 2018], with effect sizes for individual modifiers reported inconsistently across study designs and grading conventions.